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Table 3 List of QI’S

From: The development of electronic health record—extractable quality indicators for osteoporosis in primary care: A rand-modified Delphi method

List of QI’S

EHR-extractability

DIAGNOSIS

 

1) Percentage of patients with history of a fragility fracture* and/or a T-score of -2.5 or lower on 'dual energy X-ray absorptiometry' (DXA) in the lumbar spine (antero-posterior), femoral neck, hip or 1/3 radius who were diagnosed with osteoporosis

Adjustments EHR necessary

SCREENING

2) Percentage of patients under the age of 50 with one or more clinical risk factor¥

who were screened for osteoporosis by calculating FRAX (Fracture Risk Assessment Tool) every 2 years

Adjustments EHR necessary

3) Percentage of postmenopausal women or men ≥ 50 years of age with

- one or more clinical risk factor¥ for fragility fracture

or/and

- current smoking

or/and- age > 65 years

who were screened for osteoporosis by calculating the FRAX score every 2 years

Adjustments EHR necessary

4) The percentage of patients with risk factors for developing secondary osteoporosis i.e.:

- Rheumatoid arthritis, Crohn’s disease, ulcerative colitis,

- Hypercortisolaemia (Cushing’s syndrome), hyperthyroidism, hyperparathyroidism, hyperprolactinaemia,

- Early menopause**

- Male hypogonadism, diabetes mellitus type I and II,

- Chronic liver disease, gastrointestinal resection or bypass, celiac disease, malabsorption, lactose intolerance,

- Alcoholism, anorexia nervosa, calcium deficiency, vitamin D deficiency,

- eGFR < 60 ml/ min/1.73 m2,

- Glucocorticoids, aromatase inhibitors, gonadotropin-releasing hormone agonists, Tamoxifen, chemotherapy,

- Paraplegia, quadriplegia,

- Asthma, chronic obstructive pulmonary disease,

- Parkinson’s disease, multiple sclerosis, stroke,

who were screened for osteoporosis by calculating the FRAX score every 2 years

Adjustments EHR necessary

TECHNICAL INVESTIGATIONS

5) The percentage of patients with osteoporosis in whom subsequent blood tests were investigated once after the diagnosis:

- Complete formula

- Creatinine

- Serum calcium

- Phosphate

- 25-OH vitamin D

- Total protein

- Albumin

- TSH

- Alkaline phosphatases

- Ferritin, Fe and transferrin

EHR-extractable at present

6) The percentage of patients with

- A history of fragility fracture*

or/and

- Two or more risk factors: one or more clinical risk factors¥, age > 65 years or active smoking;

or/and

- A FRAX score for primary fracture ≥ 5%

or/and

- Treatment with aromatase inhibitors, antiandrogens for 3 months or longer (both current, prior and cumulative use)

who had a DXA

Adjustments EHR necessary

LIFESTYLE MANAGEMENT

7) The percentage of patients with osteoporosis who were advised to stop smoking

EHR-extractable at present

8) The percentage of patients with osteoporosis who were advised to limit alcohol use to ≤ 2 units per day

EHR-extractable at present

9) The percentage of patients who either had a fracture or a fall ≥ 1/ year who were referred for physiotherapy (fall prevention and rehabilitation)

Adjustments EHR necessary

10) The percentage of patients with osteoporosis who were advised to engage in physical activity

EHR-extractable at present

TREATMENT

11) Percentage of patients with osteoporosis who take 800–1.000 IU vitamin D per day

EHR-extractable at present

12) Percentage of patients > 50 years with vitamin D deficit < 30 ng

AND a clinical risk factor¥ for osteoporosis or current smokers

who take 800–1000 IU vitamin D per day

EHR-extractable at present

13) Percentage of patients > 65 years with a clinical risk factor¥ for osteoporosis or current smokers who take 800–1000 IU vitamin D per day

EHR-extractable at present

14) Percentage of patients with osteoporosis who have calcium intake of 1200 mg/day or ≥ 4 diary portions a day

Adjustments EHR necessary

15) Percentage of postmenopausal women and patients over 50 years old who had a major osteoporotic fracture$ in the past 2 years receiving pharmacological osteoporosis treatment now or have received treatment in the past

Adjustments EHR necessary

16) Percentage of patients with FRAX 10-year probability of major osteoporotic fracture$ ≥ 20% or a 10-year probability of a hip fracture of ≥ 3% or ≥ 5% for patients aged ≥ 70 years who receive pharmacological osteoporosis treatment

Adjustments EHR necessary

17) Percentage of patients with T-scores ≤—2.5 at the lumbar spine, femoral neck or total hip region receiving pharmacological osteoporosis treatment

Adjustments EHR necessary

18) Percentage of patients with osteoporosis with:

- No fragility fracture* in the last 2 years or/and

- T-score ≤ -2,5 and > -3.5 or/and

- FRAX risk of major osteoporotic fracture$ ≥ 20% and < 30%, or hip fracture ≥ 3% and < 4.5%

receiving oral bisphosphonates during 5 years as first line therapy if not contraindicated and well tolerated

Adjustments EHR necessary

19) Percentage of osteoporosis patients with one or more of the following:

-Barrett esophagus,

-Esophageal abnormalities,

-Gastric ulcers,

-Gastric bypass,

-Severe GERD,

-Malabsorption

-Chronic renal insufficiency eGFR < 35 ml/min

who do not receive oral bisphosphonates

EHR-extractable at present

20) Percentage of osteoporosis patients with

- Gastrointestinal contra-indications and

- eGFR ≥ 35 ml/min and

- No fragility fracture* in the last 2 years and/or

- T-score ≤ -2,5 and > -3.5 and/or

- FRAX risk of major osteoporotic fracture$ ≥ 20% and < 30%, or hip fracture ≥ 3% and < 4.5%

receiving intravenous bisphosphonates once a year for three years

Adjustments EHR necessary

21) Percentage of osteoporosis patients with

- eGFR < 35 ml/min and

- No fragility fracture* in the last 2 years or/and

- T-score ≤ -2,5 and > -3.5 or/and

- FRAX risk of major osteoporotic fracture$ ≥ 20% and < 30%, or hip fracture ≥ 3% and < 4.5%

receiving subcutaneous Denosumab every six months as first line treatment

Adjustments EHR necessary

22) Percentage of osteoporosis patients treated with Zoledronate after a hip fracture

EHR-extractable at present

23) Percentage of osteoporosis patients receiving Denosumab in whom their serum calcium levels were checked 2 weeks prior treatment during the first year of treatment

EHR-extractable at present

24) Percentage of osteoporosis patients with eGFR < 35 ml/min receiving Denosumab in whom their serum calcium levels were checked 2 weeks prior and 2 weeks after treatment during the first year of treatment

EHR-extractable at present

FOLLOW-UP

25) Percentage of osteoporosis patients who had annual check-ups with measurements of height and weight, control of compliance, checking for fractures or fall incidents and assessment of risk factors

Adjustments EHR necessary

26) Percentage of osteoporosis patients taking bisphosphonates who had annual check of creatinine, calcium and vitamin D

EHR-extractable at present

27) Percentage of osteoporosis patients taking zoledronate for 3 years or alendronate for 5 years with a risk factor i.e

- T score after 3 years of treatment < -2.5

or/and

- age > 75 years

or/and

- history of hip or vertebral fracture

or/and

- one or more fractures due to minimal trauma during treatment

or/and

- current treatment with oral glucocorticoids ≥ 5 mg prednisolone daily or equivalent

in whom zoledronate is continued for an additional 3 or 5 years respectively

Adjustments EHR necessary

28) Percentage of osteoporosis patients with T- score higher than -2.5 after taking zoledronate for 3 years/ alendronate for 5 years in which treatment is discontinued

Adjustments EHR necessary

29) Percentage of osteoporosis patients in whom bisphosphonates are discontinued after 3–5 years who receive a control BMD after 2 years or in case of new fragility fracture*

Adjustments EHR necessary

REFERRAL

30) Percentage of patients < 50 years with a fragility fracture* who are referred to a specialist

Adjustments EHR necessary

31) Percentage of osteoporosis patients with ≥ 2 new fractures despite > 1 year of treatment with bisphosphonates and good compliance who are referred to a specialist

Adjustments EHR necessary

32) Percentage of osteoporosis patients with GFR < 15 ml/min/1.73 m2 who are referred to a specialist

EHR-extractable at present

33) Percentage of pre-menopausal women and men < 50 years with a T score -2,5 who are referred to a specialist

Adjustments EHR necessary

34) Percentage of osteoporosis patients with:

- a fragility fracture* in the last 2 years

or/and

- multiple (≥ 2) fragility fractures*

or/and

- a T-score < -3.5

or/and

- FRAX risk of major osteoporotic fracture$ > 30%, hip fracture > 4.5%

who are referred to a specialist

Adjustments EHR necessary

  1. Legend: *Fragility fracture, Fracture sustained by a force similar to a fall from a standing position or less (most common is vertebral, pelvic, hip, femoral, humeral or forearm fracture). **Early menopause, < 45 years
  2. $Major osteoporotic fracture, Presence of a vertebral, pelvic, hip, femoral or humeral fracture or forearm fracture in patients ≥ 75 years old
  3. ¥Clinical risk factors, Body mass index < 20 kg/m2, History of fragility fracture, History of hip fracture in either parent, 5 mg of prednisolone per day or equivalent for longer than 3 months, Alcohol intake > 3units/day, Frequent falls (≥ 1/year), Early non-substituted menopause
  4. §Contraindications bisphosphonates, Barrett esophagus, Esophageal abnormalities, Gastric ulcers, Gastric bypass,Severe GERD,Malabsorption, Chronic renal insufficiency eGFR, < 35 ml/min