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Table 3 Cox regression analysis evaluating predictors to suffer a new MACE in the study population

From: Classification rule for ten year MACE Risk in primary care tarragona older adults with type2 diabetes: a CHAID decision-tree analysis

 

T2DM

without previous MACE

and NO NEW MACE

N = 3887

(83.3%)

T2DM without previous MACE

and NEW MACE

N = 779

(16.7%)

Unadjusted HR

(95% CI), p

Multivariable-adjusted HR

(95% CI), p

Age, years

71.1 (7.9)

73.4 (8)

1.06 (1.05–1.07), < 0.001

1.06 (1.05–1.07), < 0.001

Sex, male

1782 (45.8)

2105 (54.2)

362 (46.5)

417 (53.5)

1.02 (0.88–1.18), 0.77

1.3 (1.03–1.65), 0.03

Hypertension

2642 (68)

587 (75.4)

1.43 (1.22–1.69), < 0.001

1.18 (0.98–1.44), 0.09

Chronic pulmonary disease

338 (8.7)

60 (7.7)

1.48 (1.14–1.93), 0.004

1.37 (1.03–1.83), 0.03

Chronic liver disease

128 (3.3)

17 (2.2)

0.76 (0.47–1.22), 0.25

0.87 (0.53–1.44), 0.58

Chronic renal disease

104 (2.7)

30 (3.9)

1.99 (1.38–2.87), < 0.001

1.2 (0.79–1.83), 0.39

Current smoking

419 (10.8)

80 (10.3)

0.93 (0.73–1.17), 0.53

0.95 (0.69–1.3), 0.74

Obesity

1286 (33.1)

270 (34.7)

1.1 (0.95–1.27), 0.21

1.31 (1.05–1.65), 0.02

Dyslipidaemia

1783 (45.8)

351 (45.1)

0.74 (0.48–1.14), 0.17

1.04 (0.89–1.22), 0.65

SBP_basal, No control

1958 (50.4)

413 (53)

1.08 (0.94–1.24), 0.3

0.94 (0.75–1.19), 0.6

Total cholesterol_basal, No control

78 (2)

13 (1.7)

1.78 (1.03–3.08), 0.04

3.14 (1.74–5.66), < 0.001

HDL-cholesterol_basal, No control

790 (20.3)

199 (25.5)

1.54 (1.31–1.81), < 0.001

1.49 (1.19–1.87), < 0.001

LDL-cholesterol_basal, No control

2554 (65.7)

507 (65.1)

0.92 (0.79–1.06), 0.22

0.98 (0.76–1.26), 0.87

Glucose_basal, No control

689 (17.7)

137 (18)

1.33 (1.11–1.60), 0.002

1.32 (1.01–1.66), 0.01

HbA1c_basal, No control

589 (15.2)

129 (16.6)

1.33 (1.1–1.61), 0.003

1 (0.77–1.29), 0.98

BMI_08, Kg/m2

30.4 (4.9)

30.6 (5.2)

1 (0.98–1), 0.78

0.99 (0.97–1.01), 0.59

SBP_08, mmHg

139.5 (18.2)

140.7 (19.5)

1 (0.99–1), 0.14

1 (1–1.01), 0.02

DBP_08, mmHg

76.1 (9.9)

74.8 (10.5)

0.98 (0.98–0.99), < 0.001

0.99 (0.98–0.99), 0.003

Glucose_08, mg/dl

146.1 (51.9)

149.4 (56.8)

1 (1–1.003), 0.04

1 (0.99–1), 0.57

HbA1c_08, % mean (SD)

6.8 (1.5)

6.9 (1.6)

1.06 (1.01–1.11), 0.02

1.05 (0.98–1.12), 0.2

Total Cholesterol_08, mg/dl

197.3 (37.9)

195.2 (41.7)

0.99 (0.99–1), 0.04

0.99 (0.99–1), 0.55

LDL-Cholesterol_08, mg/dl

118.2 (32)

116.9 (34.7)

0.99 (0.99–1), 0.11

1 (0.99–1.01), 0.59

HDL-Cholesterol_08, mg/dl

50.8 (12.6)

48.8 (12.2)

0.98 (0.98–0.99), < 0.001

0.99 (0.98–1), 0.14

  1. Data are presented with frequencies (%), or the mean (standard deviation), according to the type of variable (categorical or continuous variables, respectively)
  2. MACE major adverse cardiovascular events, T2DM Type 2 Diabetes Mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, LDL low-density lipoprotein, HDL high-density lipoprotein, HbA1c aemoglobin A1c, BMI body mass index
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